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Professor |
Courses
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Graduate |
Undergraduate |
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BME595B: Biomolecular Engineering BME595J: Molecular/Cellular Biomechanics |
BME354: Cell/Tissue Behavior and Properties |
Research Projects
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Joint Loading (in
vivo) |
Mechantransduction (in
vitro) |
Systems Biology (in
silico) |
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A joint-loading modality (loads applied to
the knee, ankle, or elbow) is capable of promoting bone formation and
accelerating healing of wounded bone.
We are investigating biophysical and molecular mechanisms underlying
joint loading. |
Fluid flow to osteoblasts cells, osteocyte
cells & chondrocytes activates various molecular pathways and alter gene
expression. We are analyzing
load-driven molecular pathways linked to cellular proliferation,
differentiation, inflammation, and apoptosis. |
Cis-acting regulatory DNA and RNA elements
play a critical role in transcription, splicing, and translation. We are interested in identifying various
cis-acting elements in a genome scale using math models & computational
simulations. |
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Zhang et
al. (2008). BJSM [Epub] Zhang et
al. (2007). JBMR 22:1979-87 Zhang et
al. (2007). Bone 40:1320-8 Zhang et
al. (2007). Bone 40:538-43 |
Hamamura et al. (2008). JBMM [Epub] Hamamura et al. (2007). FEBS
Lett 581:1769-74 Chen et
al. (2007). GPB 5:158-65 Tanaka et
al. (2005). Cal
Tissue Int 76:261-71 |
Choi et
al. (2007). FEBS Lett 581:2684-90 Liu et
al. (2006). BMC Genomics 7:221 Liu et
al. (2005). BMC
Bioinform 6:276 Liu
et al. (2004). Systems
Biol 1:85-92 |
PubMed
(Yokota H) AND (co-Authors)
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Research Team |
Links |
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Contact
Information |
Other
Links |
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e-mail:
hyokota (at) iupui (dot) edu |
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