Hiroki Yokota, PhD2



     Biomedical Engineering

      Anatomy & Cell Biology

      Mechanical Engineering


Biographical Sketch






BME595B: Biomolecular Engineering

BME595J: Molecular/Cellular Biomechanics



BME354: Cell/Tissue Behavior and Properties



Research Projects

Joint Loading

(in vivo)


(in vitro)

Systems Biology

(in silico)

A joint-loading modality (loads applied to the knee, ankle, or elbow) is capable of promoting bone formation and accelerating healing of wounded bone.  We are investigating biophysical and molecular mechanisms underlying joint loading.


Fluid flow to osteoblasts cells, osteocyte cells & chondrocytes activates various molecular pathways and alter gene expression.  We are analyzing load-driven molecular pathways linked to cellular proliferation, differentiation, inflammation, and apoptosis.

Cis-acting regulatory DNA and RNA elements play a critical role in transcription, splicing, and translation.  We are interested in identifying various cis-acting elements in a genome scale using math models & computational simulations.

Zhang et al. (2008). BJSM [Epub]

Zhang et al. (2007). JBMR 22:1979-87

Zhang et al. (2007). Bone 40:1320-8

Zhang et al. (2007). Bone 40:538-43


Hamamura et al. (2008). JBMM [Epub]

Hamamura et al. (2007). FEBS Lett 581:1769-74

Chen et al. (2007). GPB 5:158-65

Tanaka et al. (2005). Cal Tissue Int 76:261-71

Choi et al. (2007). FEBS Lett 581:2684-90

Liu et al. (2006). BMC Genomics 7:221

Liu et al. (2005). BMC Bioinform 6:276

Liu et al. (2004). Systems Biol 1:85-92


PubMed (Yokota H) AND (co-Authors)

Other Publications


Research Team







Contact Information

Other Links

1120 South Drive, FH 115
Indianapolis, Indiana 46202
Phone: (317) 274-2448
Fax: (317) 278-9568

e-mail: hyokota (at) iupui (dot) edu