|
|
Associate Professor |
Courses
|
Graduate |
Undergraduate |
|
BME595B: Biomolecular Engineering BME595J: Molecular/Cellular Biomechanics |
BME354: Cell/Tissue Behavior and Properties |
Research Projects
|
Joint Loading (in vivo) |
Mechantransduction (in vitro) |
Systems Biology (in silico) |
|
A joint-loading modality (loads applied to the knee,
ankle, or elbow) is capable of promoting bone formation and accelerating
healing of wounded bone. We are
investigating biophysical and molecular mechanisms underlying joint loading. |
Fluid flow to osteoblasts cells, osteocyte cells &
chondrocytes activates various molecular pathways and alter gene
expression. We are analyzing
load-driven molecular pathways linked to cellular proliferation,
differentiation, inflammation, and apoptosis. |
Cis-acting regulatory DNA and RNA elements play a critical
role in transcription, splicing, and translation. We are interested in identifying various
cis-acting elements in a genome scale using math models & computational
simulation. |
|
|
|
|
|
Zhang et al. (2008). BJSM [Epub] Zhang et al. (2007). JBMR 22:1979-87 Zhang et al. (2007). Bone 40:1320-8 Zhang et al. (2007). Bone 40:538-43 |
Hamamura et al. (2008). JBMM [Epub] Hamamura et al. (2007). FEBS
Lett 581:1769-74 Chen et al. (2007). GPB 5:158-65 Tanaka et al. (2005). Cal
Tissue Int 76:261-71 |
Choi et al. (2007). FEBS Lett 581:2684-90 Liu et al. (2006). BMC Genomics 7:221 Liu et al. (2005). BMC
Bioinform 6:276 Liu et al. (2004). Systems
Biol 1:85-92 |
PubMed
(Yokota H) AND (co-Authors)
|
Research Team |
Links |
|
|
|
|
Contact
Information |
Other
Links |
|
e-mail: hyokota (at) iupui (dot) edu |
|
